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Why Collagen Often Has No Effect

Author: Ana Gómez 

published on 2026-01-14

More and more women aged 35 and over are turning to collagen to counteract age-related skin changes:

  • decreasing skin elasticity,
  • slower regeneration,
  • changes in nails and hair.

Unfortunately, despite regular collagen intake, the desired effect often fails to materialize. This gives the impression that collagen generally has no effect. A big mistake.

Why collagen often has no effect

In most cases, the problem is not with the collagen itself, but with its quality and how it's taken:

  • Low bioavailability: Collagen that is not optimally broken down can only be processed to a limited extent by the body.
  • Diluted formulations: Flavorings and fillers increase volume and reduce product costs, but do not contribute to efficacy.
  • High dose instead of quality: Many suppliers recommend up to 15 grams of collagen daily to compensate for low efficacy.

These three factors lead to high dosages with low biological efficiency. The desired effect is not achieved.

How Our Collagen Peptides Differ

For collagen to be effective, it must be in a form that the body can utilize. The keyword here is: collagen peptides.

 

To ensure bioavailability and quality, some suppliers use branded raw materials like Verisol® B. These are:

  • clinically tested, bioactive collagen peptides with
  • an optimized peptide structure for high absorption.

Thanks to the targeted formulation and high quality, just 2.5 g of collagen daily is enough to achieve clinically proven results.

The benefits of Medicom Collagen Peptides

1. Support for the house structure

Collagen Types I and III are key components of the skin. Targeted supplementation can help support the skin's firmness and elasticity – from within.

2. Contribution to Nails, Hair, and Connective Tissue

As a structural building material, collagen also plays a role in nails, hair, and connective tissue. This support becomes more relevant with increasing age. 

3. Reduced Dosage with Clear Justification

Thanks to the high bioavailability of the bioactive collagen peptides, a daily amount of 2.5 g is sufficient. This allows for simple, continuous use without much effort.

Collagen Peptides by Medicom

If you don't judge collagen by grams, but by biological effectiveness, then Medicom's collagen peptides are worth a look. 

 

A daily dose costs - despite the high quality - less than 50 cents. And with the 90-day money-back guarantee, you can try the product risk-free.


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Collagen Peptides
 

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150 gr / 60 servings 

Only 25.90
 

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Collagen Peptides

4-Month Premium Package

300 gr / 120 Servings
 
Only €44.03 €51.80

 

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What do collagen peptides really do?

Collagen powder provides the body with the building blocks it needs to regenerate skin, hair, nails, joints, and connective tissue.  

The hydrolyzed collagen in peptide form is particularly well absorbed and acts as a signaling molecule in the body: It activates fibroblasts in the skin, which then produce more of the body's own collagen. This strengthens the skin structure, can reduce wrinkles, and improves moisture. Prerequisite: It must be a collagen with clinically proven effectiveness - such as VERISOL® B.  

In addition, tendons, ligaments, and cartilage also benefit, which makes collagen powder particularly interesting for active athletes and older people.  

What exactly is in collagen peptides – and why is it important for skin & hair?

Collagen peptides consist of short chains of specific amino acids which, when ingested, specifically activate skin regeneration processes in the body – especially the body's own production of collagen, elastin, and hyaluronic acid.

The most important amino acids in collagen are glycine, proline, and hydroxyproline. They play a central role in the structure, elasticity, and firmness of the skin – as they form the framework of the collagen fibers in the connective tissue.

However, with increasing age, the body's own production of collagen decreases. The consequence: The skin loses elasticity, becomes drier, and shows the first lines and wrinkles. This is exactly where hydrolyzed collagen peptides come in: Collagen is broken down with water and enzymes, making it particularly small (around 2,000 Daltons). The body can absorb and utilize them more easily.

VERISOL® B collagen peptides specifically deliver the bioactive collagen building blocks your skin needs to stimulate its own collagen synthesis again. Studies show: The skin becomes more elastic, smoother, and visibly fresher – from the inside out.

In short: The ingredients of collagen peptides provide your body with exactly what it needs to strengthen its natural skin structure and effectively slow down the aging process.

Does collagen help for shiny, strong hair? 

Yes, collagen can also contribute to hair and nail care – provided it is bioactive collagen peptides with proven efficacy. The amino acids contained, especially glycine, proline, and hydroxyproline, support the formation of keratin – the main component of hair and nails.
 

For hair, studies show: Bioactive collagen peptides can promote hair growth, improve hair density, and shorten the resting phase of hair follicles – a potential benefit, e.g., for hormonal changes or age-related hair loss¹.
 

For nails, it has been demonstrated: Taking 2.5 g of collagen peptides daily for 24 weeks reduced nail brittleness by 42%, improved nail growth, and increased firmness².
 

Crucially, here too: quality, small peptide size, and daily application for at least 3 months.

 

Sources:

¹ Oesser S., 2020. The oral intake of specific bioactive collagen peptides has a positive effect on hair thickness. Nutrafoods.

² Hexsel et al., 2017. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol.

Does collagen powder help against wrinkles?

Yes, high-quality collagen powder can visibly reduce wrinkles – provided it contains bioactive collagen peptides with clinically proven efficacy. Studies with the branded ingredient VERISOL® B show: skin elasticity improves and wrinkle depth reduces – especially around the eyes and cheeks. (1) 

 

The reason: collagen peptides don't just act as building blocks – they function as signaling agents for skin cells. They stimulate fibroblasts in the dermis (the middle layer of the skin) to produce more endogenous collagen and elastin. This strengthens the skin structure from within and allows it to measurably regenerate. 

 

It is crucial that you choose a product with a small peptide size (approx. 2,000 Daltons) and proven bioavailability. Why? Only then can the peptides enter the bloodstream, act actively, and achieve long-term results. 

 

For visible results, you need one thing above all: quality and daily consistency. Ideally, take the collagen for at least 3 months – then your skin will show you the results. 

(1) E. Proksch et. al., Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis, in Skin Pharmacol Physiol (2014)

Why is the molecular size – about 2,000 Daltons – so important for collagen?

For collagen to work in the body, it must first be absorbed. Large molecules from conventional collagen powder are often too difficult to digest – the body cannot properly utilize them and simply excretes them again. 

 

Collagen peptides with a small molecular size (for example, approx. 2,000 Daltons), on the other hand, are broken down in such a way that they are particularly well absorbed and utilized by the body. After ingestion, they reach the bloodstream more quickly and stimulate skin cells to produce more of their own collagen. 

 

This is the decisive advantage: they not only act as a building block but also specifically activate the natural skin renewal from within – exactly where wrinkles form. 

 

Good to know: Dalton is a unit of measurement for molecular size – the smaller, the better the absorption in the body. 

What do collagen types I, II, and III stand for?

The different types of collagen (Type I, II, and III) perform various functions in the body. Type I and Type III are primarily found in skin, connective tissue, tendons, bones, and blood vessels – they are responsible for elasticity, strength, and structure. Type II, on the other hand, is mainly found in articular cartilage, where it provides elasticity and cushioning.

 

In a collagen hydrolysate – i.e., hydrolyzed collagen powder, such as that contained in the Medicom product Collagen Peptides – the long collagen chains are enzymatically broken down into shorter peptides. These bioavailable collagen peptides are more easily absorbed and utilized by the body. These peptides are no longer recognized by the body as "Type I, II, or III" but rather as amino acid building blocks that are used wherever the body needs them – including in joints, blood vessels, and connective tissue.

 

Therefore, a high-quality collagen hydrolysate from Type I and III can support the entire collagen metabolism – including the structures that depend on Type II. The crucial factor is not the type of collagen in the product, but the bioavailability and peptide structure of the amino acids it contains.
 

Can collagen be taken permanently and how much should I take daily?

Yes – and it is even recommended. Collagen is a natural protein that is well tolerated by the body. Since the body's own collagen production decreases from around the age of 30, long-term supplementation is advisable to counteract natural degradation. There are no known side effects from long-term use of high-quality, hydrolyzed collagen. 

 

The only important thing is to choose a product that is pure, well-tolerated, and scientifically proven. Our product meets these criteria – for daily use without compromise. 

Not all collagen is the same. When taking collagen powder, look for collagen peptides from collagen hydrolysate with a molecular size of 2,000 Daltons. For this form of collagen, a dose of 2.5 g per day is recommended.

Why do men and women like to use collagen?

As men age – just like women – the body's own collagen production decreases. This affects not only skin and connective tissue, but also joints, tendons, and blood vessels. Collagen peptides of type I & III can specifically help here: They promote the structural strength of tissues, improve regeneration after training, and – thanks to the amino acid L-arginine, which is naturally present in collagen – contribute to vascular health and blood circulation.

*Sources:

J Calleja-Agius, Y Muscat-Baron, M P Brincat, NCBI, "Skin ageing", at https://pubmed.ncbi.nlm.nih.gov/17540135/

E Proksch, D Segger, J Degwert, M Schunck, V Zague, S Oesser, NCBI, "Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study", at: https://pubmed.ncbi.nlm.nih.gov/23949208/

E Proksch, M Schunck, V Zague, D Segger, J Degwert, S Oesser, NCBI, "Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis", at: https://pubmed.ncbi.nlm.nih.gov/24401291/

Michael Schunck, Vivian Zague, Steffen Oesser, Ehrhardt Proksch, NCBI, "Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology, at: https://pubmed.ncbi.nlm.nih.gov/26561784/

Doris Hexsel, Vivian Zague, Michael Schunck, Carolina Siega, Fernanda O Camozzato, Steffen Oesser, NCBI, "Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails", at https://pubmed.ncbi.nlm.nih.gov/28786550/https://pubmed.ncbi.nlm.nih.gov/28786550/

 

Disclaimer: 
This information is not a substitute for medical diagnosis or treatment. Please consult a healthcare professional for any health concerns. Before/after images are examples; individual results may vary.

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