Collagen Peptides – Detailed Information

What exactly are collagen peptides – and what do they consist of?

Collagen peptides are the smaller building blocks of natural collagen protein . Through a process called hydrolysis, collagen is broken down enzymatically with water and enzymes. This creates short amino acid chains (peptides) that are particularly well absorbed by the body, resulting in high and particularly good bioavailability.

High-quality collagen peptides consist primarily of the amino acids glycine, proline, and hydroxyproline , but also arginine or L-arginine , alanine, lysine , and glutamic acid . These are essential for the structure and firmness of the skin.

Particular attention is paid to the bioactive dipeptides prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly) – they have been proven to stimulate collagen synthesis in the skin and support natural skin regeneration.

How does collagen support the natural skin structure?

Collagen is your skin's most important structural protein – it provides firmness, volume, and elasticity. However, from around the age of 30, the body's own production steadily declines. The result: The skin becomes thinner, drier, loses firmness and elasticity, and begins to show lines and wrinkles. This is precisely where the "beauty from within" trend comes in.

Collagen peptides are considered a smart beauty upgrade because they strengthen skin structure from within – and this is scientifically proven. They can be easily integrated into everyday life (for example, in beverages such as water, coffee, tea, or smoothies), are well-tolerated, and perfectly fit the self-care consciousness of modern users.

Social media trends, celebrity endorsements, and studies are further fueling the hype – terms like glow, skin boost, or anti-aging drink are making collagen one of the most sought-after beauty supplements today.

But: Not all collagen works the same.

What do clinical studies say about the effects of collagen peptides on the skin?

The effectiveness of high-quality collagen peptides has now been proven by several studies.

A clinical study by Proksch et al. (2025) showed that daily intake of 2.5 g of VERISOL® B for 8 weeks in women between 35 and 55 years of age resulted in a 25% reduction in eye wrinkles , a 9% increase in skin elasticity , and a 26% improvement in skin hydration . Cell culture experiments also confirmed increased biosynthesis of type I collagen, elastin, and proteoglycans.

Source: Proksch et al., 2025. The Oral Intake of Specific Bovine-Derived Bioactive Collagen Peptides Has a Stimulatory Effect on Dermal Matrix Synthesis and Improves Various Clinical Skin Parameters. Cosmetics 2025, 12(2), 79

Other studies, such as those by Inoue et al. (2016), also show that collagen peptides with a high proportion of Pro-Hyp and Hyp-Gly significantly improve skin structure, wrinkle depth and elasticity – while being highly tolerable and without side effects.

The randomized, double-blind, placebo-controlled study by Inoue et al. showed that participants who took a collagen hydrolysate with high levels of Pro-Hyp and Hyp-Gly experienced significant improvements in skin hydration, elasticity, wrinkle depth, and skin roughness – compared to placebo or less active collagen.

Source: Inoue et al. 2016. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial aging signs in a randomized double-blind placebo-controlled clinical study in Journal of the science of food and agriculture.

What do other studies say about the effects of collagen on skin, mobility and internal structure?

Numerous clinical studies confirm the effects of collagen peptides on mobility, structural tissue, and age-related changes. The Carrillo-Norte study (2024) (1) demonstrated improved joint function and mobility. A study by Zdzieblik et al. (2021) (2) significantly reduced knee discomfort during everyday movements. According to Argyrou et al. (2020) (3), postmenopausal women also benefited from improved bone density, reduced joint pain, and stronger connective tissue structure and skin elasticity.

Conclusion: Collagen peptides can stimulate the body's own collagen production and thus specifically support mobility, resilience and tissue stability.

Sources:
1) Carrillo-Norte JA, et. al., 2024, Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study. Contemp Clin Trials Commun
(2) Zdzieblik D, et. al., 2021, The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Nutrients
(3) Argyrou C, et. al., 2020, Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia. J Musculoskeletal Neural Interact

Does collagen help build muscle? Study shows effect with strength training

Yes – a clinical study by Zdzieblik et al., 2019 showed that daily intake of 15 g of collagen hydrolysate in combination with regular strength training in older men led to a significant increase in muscle mass and strength – significantly more than in the placebo training group.

The participants were on average 72 years old, untrained, and performed a standardized strength training program over 12 weeks. Compared to the placebo group, the collagen group built more lean muscle mass, had greater leg muscle strength, and simultaneously reduced body fat percentage to a greater extent.

The explanation: Collagen specifically delivers glycine, arginine, and hydroxyproline—amino acids that are important not only for the skin, but also for tendons, ligaments, and muscular structures. L-arginine, in particular, is considered a vascular-activating amino acid that supports blood circulation—an additional benefit for women and men focused on training, recovery, and vascular health.

Conclusion: Collagen peptides can be a useful supplement for muscle building – especially for people over 50 or for active athletes who focus on regeneration, joint protection and muscle strength.

Source : Jendricke et al., 2019. Supplementation with Collagen Peptides in Combination with Resistance Training Improves Body Composition and Increases Muscle Strength in Elderly Sarcopenic Men. Nutrients 11 (4):892

Why is collagen interesting for men?

Collagen naturally contains amino acids like L-arginine , which are associated with the regulation of blood vessels and metabolic processes in the body. As a structural protein, collagen is widely distributed in bones, joints, muscles, tendons , and other tissues —therefore, it can be a useful daily supplement, especially for active, performance-oriented , and body-conscious men.

What types of collagen are there – and which is the right one for skin and movement?

There are different types of collagen, some of which are relevant in dietary supplements:

  • Type I : Skin, bones, tendons, ligaments, teeth – for skin structure, skin tightening, elasticity, strong tendons and bones
  • Type III : Skin, connective tissue, blood vessels, organs – complements Type I, improves the structure of connective tissue and vessels

Collagen types I & III are ideally suited to movement and structure from within – to support skin, hair, nails, connective tissue, tendons, joints, cartilage, bones and blood vessels.

Why do many conventional collagen powders have little to no effect?

Many inexpensive collagen supplements contain non-specific collagen protein in molecular structures that are too large. These are poorly absorbed by the body and have little or no effect.

In addition, there is often a lack of transparency, studies, or defined peptide profiles. Many products contain additives, sugar, flavorings, or inferior raw materials.

A good collagen supplement should meet the following requirements:

  • Clinically tested peptides with proven efficacy, existing studies on VERISOL® B (1)
  • 2,000 Dalton peptide size for optimal absorption and better bioavailability
  • GRAS status (recognized as safe by the FDA)
  • 100% pure collagen hydrolysate – no additives

This is how you achieve proven effective results – with only 2.5 g per day.

Sources for 1:

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