Medicom

Advertorial

Collagen not working? These are the most common reasons

Author: Ana Gómez, Micronutrient Expert 

published on 2026-01-14

More and more women over 35 – especially over 50 – are turning to collagen to counteract age-related skin changes:

  • decreasing skin elasticity,
  • slower regeneration,
  • changes in nails and hair.

Unfortunately, the desired effect often fails to materialize despite regular collagen intake. This quickly creates the impression that collagen generally has no effect. A big mistake.

Why Collagen Often Doesn't Work

In most cases, the problem isn't with the collagen itself, but with its quality and the way it's consumed:

  • Focus on quantity over quality: Many products recommend up to 15 grams of collagen daily to compensate for low efficacy.
  • Low bioavailability: Collagen that is not optimally broken down can only be processed to a limited extent by the body.
  • Diluted formulas: Flavorings and fillers increase volume but do not contribute to the effect.

These three factors often lead to high dosages with simultaneously low biological efficiency. The desired effect is not achieved.

What matters for effective collagen

The collagen must be in a form that the body can specifically utilize. The keyword here is: bioavailability through peptides.

 

To guarantee the quality of the product, Medicom's collagen peptides are based on the branded raw material Verisol® B. These are:

  • clinically studied, bioactive collagen peptides with
  • optimized peptide structure for high absorption
  • and a focus on collagen Type I & III.

Thanks to the targeted formulation and high quality, just 2.5 g of collagen daily is sufficient to achieve clinically proven results.

The Benefits of Bioactive Collagen Peptides

1. Support of the house structure

Collagen Types I & III are central components of the skin. Targeted supplementation can help support the skin's firmness and elasticity – from within.

2. Contribution to Nails, Hair, and Connective Tissue

As a structural building material, collagen also plays a role for nails, hair and connective tissue. With increasing age, this support becomes more relevant.

3. Reduced dosage with clear rationale

Thanks to the high bioavailability of the bioactive collagen peptides, a daily amount of 2.5 g is sufficient. This allows for simple, continuous use without much effort.

Collagen Peptides from Medicom

If you don't want to judge collagen by grams, but by biological effectiveness, it's worth taking a look at Medicom's collagen peptides. With a 90-day money-back guarantee, you can try the product risk-free.


1 x Bioactive
Collagen Peptides
 

Trial Pack 

150 gr / 60 Servings 

Only 25.90
 

Order now

Money-back guarantee


4 x Bioactive
Collagen Peptides
 

4-Month Intensive Treatment

600 gr / 240 servings 
Only 77.70 103.60 €
 

Order now

Money-back guarantee - Free shipping


2 x Bioactive
Collagen Peptides
 

2 Month Premium Packet

300 gr / 120 servings 
Only 44.02 51.80 €

 

Order now

Money-back guarantee - Free shipping

2 x Bioactive
Collagen Peptides

4-Month Premium Package

300 g / 120 servings
 
Only €44.03 €51.80

 

Order now

Bioactive Collagen Peptides

Get a discount

✔️ 90-day money-back guarantee

✔️ With 25% discount: while stocks last

00
Day
00
Hour
00
Minute

What are the real benefits of collagen peptides?

Collagen powder provides the body with the building blocks it needs to regenerate skin, hair, nails, joints, and connective tissue.  

Hydrolyzed collagen in peptide form is particularly well absorbed and acts as a signaling agent in the body: It activates fibroblasts in the skin, which then produce more of the body's own collagen. This strengthens the skin structure, can reduce wrinkles, and improves moisture. Prerequisite: It must be a collagen with clinically proven effectiveness – such as VERISOL® B. 

In addition, tendons, ligaments, and cartilage also benefit, which makes collagen powder particularly interesting for active athletes and older people. 

What exactly is in collagen peptides – and why is it important for skin & hair?

Collagen peptides consist of short chains of specific amino acids which, when ingested, specifically activate processes of skin regeneration in the body – especially the body's own production of collagen, elastin, and hyaluronic acid.

The most important amino acids in collagen are glycine, proline, and hydroxyproline. They play a central role in the structure, elasticity, and firmness of the skin – as they form the framework of the collagen fibers in the connective tissue.

However, with increasing age, the body's own production of collagen decreases. The result: The skin loses elasticity, becomes drier, and shows initial lines and wrinkles. This is exactly where hydrolyzed collagen peptides come in: Collagen is broken down with water and enzymes, making it particularly small (approx. 2,000 Daltons). The body can absorb them more easily and utilize them better.

VERISOL® B collagen peptides specifically deliver the bioactive collagen building blocks that your skin needs to stimulate its own collagen synthesis again. Studies show: The skin becomes more elastic, smoother, and visibly fresher – from the inside out.

In short: The ingredients in collagen peptides provide your body with exactly what it needs to strengthen its natural skin structure and effectively slow down the aging process.

Does collagen help for shiny, strong hair? 

Yes, collagen can also contribute to the care of hair and nails – provided it is bioactive collagen peptides with proven efficacy. The amino acids it contains, especially glycine, proline, and hydroxyproline, support the formation of keratin – the main component of hair and nails.
 

For hair, studies show: Bioactive collagen peptides can promote hair growth, improve hair density, and shorten the resting phase of hair follicles – a potential benefit, for example, in cases of hormonal changes or age-related hair loss¹.
 

For nails, it has been demonstrated: Taking 2.5 g of collagen peptides daily for 24 weeks reduced nail brittleness by 42%, improved nail growth, and increased nail strength².
 

Crucially, here too, are: quality, small peptide size, and daily application for at least 3 months.

 

Sources:

¹ Oesser S., 2020. The oral intake of specific bioactive collagen peptides has a positive effect on hair thickness. Nutrafoods.

² Hexsel et al., 2017. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol.

Does collagen powder help against wrinkles?

Yes, high-quality collagen powder can visibly reduce wrinkles – provided it contains bioactive collagen peptides with clinically proven efficacy. Studies with the branded raw material VERISOL® B show: skin elasticity improves and wrinkle depth reduces – especially in the eye and cheek area. (1) 

 

The reason: collagen peptides don't simply act as building blocks – they function as signaling agents for skin cells. They stimulate fibroblasts in the dermis (the middle layer of the skin) to produce more endogenous collagen and elastin. This way, the skin structure is strengthened from within and can regenerate measurably. 

 

It is crucial to choose a product with a small peptide size (around 2,000 Daltons) and proven bioavailability. Why? Only then can the peptides enter the bloodstream, act actively, and achieve long-term results. 

 

For visible results, you primarily need one thing: quality and daily consistency. Ideally, take collagen for at least 3 months – then your skin will show you the results. 

(1) E. Proksch et. al., Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis, in Skin Pharmacol Physiol (2014)

Why is molecular size – about 2,000 Daltons – so important for collagen?

For collagen to be effective in the body, it must first be absorbed. Large molecules from conventional collagen powder are often too difficult to digest – the body cannot properly utilize them and simply excretes them again. 

 

Collagen peptides with a small molecular size (for example, around 2,000 Daltons), however, are broken down in such a way that they are particularly well absorbed and utilized by the body. After ingestion, they reach the bloodstream faster and stimulate skin cells to produce more of their own collagen. 

 

This is the decisive advantage: they not only act as a building material but also specifically activate natural skin renewal from within – precisely where wrinkles originate. 

 

Good to know: Dalton is a unit of measurement for molecular size – the smaller it is, the better the absorption in the body. 

What do Collagen Type I, Type II, and Type III stand for?

The different collagen types (Type I, II, and III) perform various functions in the body. Type I and Type III are found primarily in skin, connective tissue, tendons, bones, and blood vessels – they are responsible for elasticity, firmness, and structure. Type II, on the other hand, is mainly found in articular cartilage, where it provides elasticity and cushioning.

 

In a collagen hydrolysate – i.e., hydrolyzed collagen powder, as contained in the Medicom product Collagen Peptides – the long collagen chains are enzymatically broken down into shorter peptides. These bioavailable collagen peptides are more easily absorbed and utilized by the body. These peptides are no longer recognized by the body as "Type I, II, or III" but as building blocks of amino acids, which are used wherever the body needs them – including in joints, blood vessels, and connective tissue.

 

Therefore, a high-quality collagen hydrolysate from Type I and III can support the entire collagen metabolism – including the structures that depend on Type II. The crucial factor is not the collagen type in the product, but the bioavailability and peptide structure of the contained amino acids.
 

Can collagen be taken permanently and how much should I take daily?

Yes – and it is even recommended. Collagen is a natural protein that is well tolerated by the body. Since the body's own collagen production decreases from about 30 years of age, long-term supplementation is useful to counteract the natural degradation. There are no known side effects with long-term intake of high-quality, hydrolyzed collagen. 

 

The only important thing is to choose a product that is pure, well-tolerated and scientifically proven. Our product meets these criteria – for daily use without compromise. 

Collagen is not just collagen. When taking collagen powder, look for collagen peptides from collagen hydrolysate with a molecular size of 2,000 Daltons. For this form of collagen, a dose of 2.5 g per day is recommended.

Why do men and women like to use collagen?

As men age – just like women – their bodies' natural collagen production decreases. This affects not only skin and connective tissue but also joints, tendons, and blood vessels. Collagen peptides of type I & III can specifically help here: They promote the structural strength of tissues, improve regeneration after exercise, and – thanks to the amino acid L-Arginine, which is naturally present in collagen – contribute to vascular health and blood circulation.

*Sources:

J Calleja-Agius, Y Muscat-Baron, M P Brincat, NCBI, “Skin ageing,” at https://pubmed.ncbi.nlm.nih.gov/17540135/

E Proksch, D Segger, J Degwert, M Schunck, V Zague, S Oesser, NCBI, “Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study,” at: https://pubmed.ncbi.nlm.nih.gov/23949208/

E Proksch, M Schunck, V Zague, D Segger, J Degwert, S Oesser, NCBI, “Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis,” at: https://pubmed.ncbi.nlm.nih.gov/24401291/

Michael Schunck, Vivian Zague, Steffen Oesser, Ehrhardt Proksch, NCBI, “Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology,” at: https://pubmed.ncbi.nlm.nih.gov/26561784/

Doris Hexsel, Vivian Zague, Michael Schunck, Carolina Siega, Fernanda O Camozzato, Steffen Oesser, NCBI, “Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails,” at https://pubmed.ncbi.nlm.nih.gov/28786550/https://pubmed.ncbi.nlm.nih.gov/28786550/

 

Disclaimer: 
This offering does not replace medical diagnosis or treatment. For health concerns, please consult a specialist. Before-and-after images are examples; individual results may vary.

Popular Ingredients

Adaptogens

Medicinal plants

Minerals & trace elements

Vitamins